Being a molecular physiologist and developmental biologist in training, my primary research interest is in heart development and disease. My teaching experiences are also in the area of development and molecular biology. Currently, my research laboratory will investigate the role of Tbx20, a T-box transcription factor gene in regulation of cardiomyocyte (heart muscle cell) proliferation and Adamts4, a matrix metalloprotease in regulation of extracellular matrix remodeling during heart development and disease. As long-term goals, I am also interested in cancer biology (proliferation and cell cycle control) and developmental gene re-activation following adult cardiac diseases like myocardial infarction or heart attack.
B.Sc in Zoology (Calcutta University: 1994-1997)
M.Sc in Zoology (Calcutta University: 1997-1999)
PhD. in Molecular Physiology (Miami University, Ohio, USA: 2001-2006)
Postdoctoral Research Fellow (The Heart Institute; Cincinnati Children's Hospital Medical Center, Ohio, USA: 2006-2010)
Postdoctoral Research Associate (The Heart Institute; Cincinnati Children's Hospital Medical Center, Ohio, USA: 2010-2013)
Santanu Chakraborty, PhD, completed his doctorate degree in Molecular Physiology at the Miami University and a postdoctoral fellowship at the Cincinnati Children’s Hospital Medical Center, both in Ohio, USA. Dr. Chakraborty joined the Presidency University in April 2013 as an Assistant Professor in the Department of Biological Sciences (Zoology). He is interested in both embryonic heart development and adult heart diseases linked to cellular proliferation and extracellular matrix remodeling. His other research interests are to study the cross talk among different cardiac cell lineages including endothelial, myocardial and epicardial cells during development and disease. He is also interested in exploring the area of cardiac progenitor/stem cells and to study the functional significance of developmentally critical transcription factor gene re-activation following adult cardiac diseases using both in vivo and in vitro approaches.
Research / Administrative Experience+
Teaching / Other Experience+
Post Graduate Supervision+
American Association of Anatomists (AAA).
Member of the American Heart Association (AHA), Council on Basic Cardiovascular Science.
Life Member of Indian Society of Cell Biology (ISCB).
1) Looney MR*, Sartori C*, Chakraborty S, James PF, Lingrel JB, Matthay MA. Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2005 Jul; 289(1): L104-10; * Equal contribution.
2) Hlivko JT*, Chakraborty S*, Hlivko TJ, Sengupta S, James PF. The human Na,K-ATPase alpha4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm. Mol Reprod Dev. 2006 Jan; 73(1): 101-115; *Equal contribution.
3) Chakraborty S, Cheek J, Sakthivel B, Aronow BJ, Yutzey KE. Shared gene expression profiles in developing heart valves and osteoblast progenitor cells. Physiol Genomics. 2008 Sep 17;35(1):75-85 Epub 2008 Jul 8.
4) Alfieri CM, Cheek J, Chakraborty S, Yutzey KE. Wnt signaling in heart valve development and osteogenic gene induction. Developmental Biology 2010 Feb 15; 338(2):127-135.
5) Chakraborty S, Combs MD, Yutzey KE. Transcriptional regulation of heart valve progenitor cells. Review article. Pediatric Cardiology. 2010 Apr;13(3): 414-421.
6) Chakraborty S, Wirrig EW, Hinton RB, Merrill WH, Spicer DB, Yutzey KE. Twist1 promotes heart valve cell proliferaion and extracellular matrix gene expression during development in vivo is expressed in human diseased aortic valves. Developmental Biology 2010 Nov 1; 347(1) 167-179.
7) Chakraborty S and Yutzey KE. Tbx20 regulation of cardiac cell proliferation and lineage specialization during embryonic and fetal development in vivo. Developmental Biology 2012 Mar 1; 363(1) 234-246.
8) Sengupta A, Chakraborty S, Paik J, Yutzey KE and Evans-Anderson HJ. Fox01 is required in endothelial but not myocardial cell lineages during cardiovascular development. Developmental Dynamics 2012 Apr; 241(4): 803-813.
9) Chakraborty S, Sengupta A and Yutzey KE. Tbx20 pronotes cardiomyocyte proliferation and persistence of fetal characteristics in adult mouse hearts. Journal of Molecular and Cellular Cardiology (2013) 62: 203-213.
10) Polley A, Sen P, Sengupta A and Chakraborty S. Beta-catenin stabilization promotes proliferation and increase in cardiomyocyte number in chick embryonic epicardial explant culture. In Vitro Cellular and Developmental Biology-Animal (2017) 53:992-939.
11) Sen P, Polley A, Sengupta A and Chakraborty S. Tbx20 promotes H9c2 cell survival against oxidative stress and hypoxia in vitro. Indian Journal of Experimental Biology (2019) 57:643-655
12) Samanta J, Mondal A, Saha S, Chakraborty S, Sengupta A. Oleic acid protects from arsenic-induced cardiac hypertrophy via AMPK/FoxO/NFATc3 pathway. Cardiovascular Toxicology (2019) Sept 30 doi: 10.1007/s12012-019-09550-9. [Epub ahead of print]
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