Piyali Mukherjee

Assistant Professor

One of the major questions that have driven my research interest throughout my scientific career is to understand what determines cell survival and what triggers the cell death process. My laboratory is currently trying to understand the balance between cell death and survival mechanisms in the context of cellular metabolism with particular emphasis on the NAD+ pathway. The molecule of interest is Sarm1 (sterile alpha and TIR contianing protein 1) which is a central regulator of programmed axonal degeneration.

One major focus of the lab is to understand the underlying mechanism of dopaminergic neuronal loss as often seen in Parkinson’s disease and the role of Sam1. We use both the cellular as well as the Drosophila model for our studies using standard cell biology and molecular biology techniques to address these questions. Mitochondria which are determinants of both ‘cell survival’ through the synthesis of ATP as well as ‘cell death’ by mediating apoptosis is the central theme to our ongoing projects. We are highly interested in how mitochondrial DAMPs emanating from the damaged mitochondria mediate the inflammatory responses as well as how it crosstalk with the autophagosome-lysosomal pathway (ALP) to regulate cell death/survival.  Since NAD+ are one of the central regulators of cellular metabolism we are also trying to connect  how the NAD+ consuming enzymes like PARP1, Sirtuins as well as the pro-neurodegenerative molecule Sarm1 plays a role in these processes.

The other project we are working on is to understand whether cancer cells utilize the deranged mitochondrial signaling for their survival and uncontrolled cellular proliferation. In this context, we have initiated a project on cervical cancer that are both HPV positive as well as HPV negative to understand how mitochondrial MAVS and SARM1 plays a role in evading viral immune response and help in the improved survival of these cells. We also seek to understand whether targeting the NAD+ pathway in these cells could help devise better therapeutic strategies targeting the tumor cells as opposed to the normal cells in the tumor microenvironment.

For more details on our neurobiology research and lab details please visit:

http://neurodegenerationgroup.webs.com/

Address

Presidency University,
86/1 College Street, Kolkata - 700073,
West Bengal, India

CV Not Available
Email: piyali.biochem at presiuniv.ac.in
alternate E-mail: piyali.dbs at presiuniv.ac.in

How to Find Us

Presidency University
(Main Campus)

86/1 College Street
Kolkata 700073

Presidency University
(2nd Campus)

Plot No. DG/02/02,
Premises No. 14-0358, Action Area-ID
New Town
(Near Biswa Bangla Convention Centre)
Kolkata-700156
Contact details Presidency University Students Corner

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