Kalyan Giri
Assistant Professor
About-
My Research interest is to build a significant research program on the structure and function of HIV-1 accessory proteins that are essential for HIV infection. The HIV-1 genome encodes four accessory proteins that include Vif, Nef, Vpu and Vpr. These proteins employ an array of strategies to manipulate host cellular factors and distinguish HIV-1 as a complex retrovirus. The goal of this research is to determine the mechanisms by which HIV accessory proteins recruit their cellular binding partners, pinpoint the molecular interactions that stabilize the virus-host protein complexes, and develop biochemical assays to screen for molecules that inhibit complex formation. This approach will lead to a more detailed understanding of accessory protein structure and function and will open avenues for the development of a new class of antiretroviral drugs.
Qualifications+
M.Sc. Physics (Jadavpur University, 1999)
Post-MSc Biophysical Sciences (Saha Institute of Nuclear Physics, 2000)
PhD Biophysical Sciences (Saha Institute of Nuclear Physics, 2006)
Biography+
2013 - present : Assistant Professor, Department of Life Sciences, Presidency University, Kolkata
2007- 2013 : Research Associate, Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Maryland, USA
Research / Administrative Experience+
Teaching / Other Experience+
2013 - present : Department of Life Sciences, Presidency University
Post Graduate Supervision+
Academic Memberships+
Publications+
Chaudhuri D, Majumder S, Giri K (2024) Repurposing of drugs targeting heparan sulphate binding site of dengue virus envelope protein: an in silico competitive binding study. Molecular Diversity doi: 10.1007/s11030-024-10834-8.
Chaudhuri D, Datta J, Majumder S. Giri K (2024) In Silico Designing of Antimicrobial Peptide Cocktail Drug Against SARS-CoV-1 and SARS-CoV-2 Replisome Complex. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 94, 145–159.
Chaudhuri D, Majumder S, Datta J, Giri K. (2023) In silico designing of an epitope-based peptide vaccine cocktail against Nipah virus: an Indian population-based epidemiological study. Archives of Microbiology 205(12):380.
Chaudhuri D, Majumder S, Datta J, Giri K (2023) Exploring the chemical space for potential inhibitors against cell surface binding protein of Mpox virus using molecular fingerprint based screening approach. Journal of Biomolecular Structure and Dynamics doi: 10.1080/07391102.2023.2238087.
Majumder S, Deganutti G, Pipitò L, Chaudhuri D, Datta J, Giri K (2023) Computer-aided de novo design and optimization of novel potential inhibitors of HIV-1 Nef protein. Computational Biology and Chemistry 104:107871.
Chaudhuri D, Datta J, Majumder S, Giri K (2023) Repurposing of drug molecules from FDA database against Hepatitis C virus E2 protein using ensemble docking approach. Molecular Diversity doi: 10.1007/s11030-023-10646-2.
Datta J, Majumder S, Chaudhuri D, Giri K (2023) In silico investigation of binding propensity of hematoxylin derivative and damnacanthal for their potential inhibitory effect on HIV-1 Vpr from different subtypes. Journal of Biomolecular Structure and Dynamics 41(24):14977-14988.
Chaudhuri D, Majumder S, Datta J, Giri K (2023) Designing of nanobodies against Dengue virus Capsid: a computational affinity maturation approach. Journal of Biomolecular Structure and Dynamics 41(6):2289-2299.
Sarkar D, Majumder S, Giri K, Sabnam N (2022) In silico characterization, molecular docking, and dynamic simulation of a novel fungal cell-death suppressing effector, MoRlpA as potential cathepsin B-like cysteine protease inhibitor during rice blast infection. Journal of Biomolecular Structure and Dynamics 41(18):9039-9056.
Saha J, Chaudhuri D, Kundu A, Bhattacharya S, Roy S, Giri K (2023) Phylogenetic, structural, functional characterisation and effect of exogenous spermidine on rice (Oryza sativa) HAK transporters under salt stress. Functional Plant Biology 50(2):160-182.
Chaudhuri D, Datta J, Majumder S, Giri K (2022) In silico study on miRNA regulation and NSs protein interactome characterization of the SFTS virus. Journal of Molecular Graphics and Modelling 117:108291.
Chaudhuri D, Datta J, Majumder S, Giri K (2022) Prediction of infectivity of SARS-CoV-2 virus based on Spike-hACE-2 interaction. VirusDisease 33(3):244-250.
Majumder S, Giri K (2022) An insight into the binding mechanism of Viprinin and its morpholine and piperidine derivatives with HIV-1 Vpr: molecular dynamics simulation, principal component analysis and binding free energy calculation study. Journal of Biomolecular Structure and Dynamics 40(21):10918-10930.
Chaudhuri D, Majumder S, Datta J, Giri K (2021) In Silico Study of Mutational Stability of SARS-CoV-2 Proteins. The Protein Journal 40(3):328-340.
Majumder S, Chaudhuri D, Datta J, Giri K (2021) Exploring the intrinsic dynamics of SARS-CoV-2, SARS-CoV and MERS-CoV spike glycoprotein through normal mode analysis using anisotropic network model. Journal of Molecular Graphics and Modelling 102:107778.
Saha J, Giri K, Roy S (2020) Identification and characterization of differentially expressed genes in the rice root following exogenous application of spermidine during salt stress. Genomics 112(6):4125-4136.
Chaudhuri D, Datta J, Majumder S, Giri K (2020) In silico designing of peptide based vaccine for Hepatitis viruses using reverse vaccinology approach. Infection Genetics and Evolution 84:104388.
Saha J, Giri K (2017) Molecular phylogenomic study and the role of exogenous spermidine in the metabolic adjustment of endogenous polyamine in two rice cultivars under salt stress. Gene 609:88-103.
Ghosh U, Giri K, Bhattacharyya NP (2009) Interaction of aurintricarboxylic acid (ATA) with four nucleic acid binding proteins DNase I, RNase A, reverse transcriptase and Taq polymerase. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 74(5):1145-51.
Giri K, Scott RA, Maynard EL (2009) Molecular structure and biochemical properties of the HCCH-Zn2+ site in HIV-1 Vif. Biochemistry 48(33):7969-78.
Giri K, Maynard EL (2009) Conformational analysis of a peptide approximating the HCCH motif in HIV-1 Vif. Biopolymers 92(5):417-25.
Raychaudhuri S, Majumder P, Sarkar S, Giri K, Mukhopadhyay D, Bhattacharyya NP (2008) Huntingtin interacting protein HYPK is intrinsically unstructured. Proteins. 2008 71(4):1686-98.
Giri K, Bhattacharyya NP, Basak S (2007) pH-dependent self-assembly of polyalanine peptides. Biophysical Journal 92(1):293-302.
Giri K, Ghosh U, Bhattacharyya NP, Basak S (2003) Caspase 8 mediated apoptotic cell death induced by beta-sheet forming polyalanine peptides. FEBS Letters 555(2):380-4.
Address
Presidency University,
86/1 College Street,
Kolkata - 700073,
West Bengal, India
Email: kalyan.biochem at presiuniv.ac.in
alternate E-mail: kalyan.giri at gmail.com
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