By my academic training I am a reproductive endocrinologist. But my basic training has been on Human Physiology. After my Masters from Calcutta University I joined Benaras Hindu university with a Centre for Advanced Studies fellowship in the Department of Zoology to persue my Doctoral Studies. I joined Dr. PranabLal Pakrashi's lab. It is here that my research training began. I learned some of the basic tennets of experimentation from Dr. Pakrashi. He trained me from an untrained research scholar to a trained research scholar. And it is from him that I developed interest in Embryology and developmental biology as a whole. But I had to leave BHU and come back to Kolkata only to join IICB as a research scholar in the Reproductive biology Research Lab of Dr. Alok k. Pal and Dr. S. N. Kabir. I carried my doctoral studies and at the same time I Joined the CSIR family as a permanent employee in my same lab as a senior technician. And later I came into teaching in the early 2009 by joining Jhargram Raj College, Jhargram as an Assistant professor in the Department of Physiology. Where I was engaged in teaching Physiology to both the honours and pass students of this subject.
At the same time I was a Guest Faculty in the Post Graduate Department of Zoology, Jhargram Raj College, where I taught Animal Physiology, Cell biology, Biophysics and Bioinstrumentation, Biotechnology (theory) and Histology and Histochemistry (Practical) to PG students of this Department. During the vacations I carried out my research projects which were in Collaboration with IICB.
But now when I have joined the University my quest is to train both the UG and PG students and biuld up their research career.
Education :
2004 Ph.D. in Life Sciences, Jadavpur University, Kolkata, India.
1992 M.Sc. in Physiology, Calcutta University, Kolkata, India, Specialization in Endocrinology and Reproductive Physiology.
1990 B.Sc. with Honours in Physiology, Chemistry and Botany as subsidiary papers. Calcutta University, Kolkata, India.
The specific areas of my interest are i) Egg-activation and oocyte maturation, ii) Sperm-egg interactions, iii) factors regulating embryo implantation iv) Germ cell maturation and primordial germ cell migration, v) Reproductive toxicology vi) cell signaling cascades and molecular pathways involved in apoptotic changes in different reproductive processes vii) Embryonic stem cells as a therapeutic tool for reproductive diseases/anomalies. As for my research goal is to better understand the fundamental mechanisms of human reproductive system and related diseases and more importantly, to translate basic research findings into therapeutic applications.
Currently I am working on the etiologies of POF, and establishing an animal model for POF. We have substantiated an important role for embryonic galactosyltransferase (galTase) in the process of germ cell migration, and demonstrated that purturbation of embryonic gal Tase function in utero induced modification of its substrate recognition, or galtase-Ab -mediated neutralization of enzyme activity led to a sequel of ovarian dysfunction that characterize the basic tenets of POF. I am seriously think of developing a stem cell research lab in my department at Presidency University . Where the students will get an exposure to the techniques of isolating embryonic stem cells from mammalian embryos/organs fetal or adult which will also help me to reach my future research goals too.
Current pilot research work focuses on
1. Delineating the Gut microbiome-Extracellular vesicles-Mitochondrial-Epigenetic (GEME) Axis in Polyendocrine Metabolic Ovarian Syndrome (PMOS): A Multicentric Observational Study in Eastern India. Submitted to ANRF as a Co-PI for funding. Polyendocrine Metabolic Ovarian Syndrome (PMOS) is a multifactorial endocrine-metabolic disorder characterized by hyperandrogenism, ovulatory dysfunction, insulin resistance, obesity, chronic inflammation, and increased risks of infertility, type 2 diabetes, and cardiovascular diseases. Existing diagnostic and therapeutic approaches are largely symptom-based and fail to address the underlying biological mechanisms. Emerging evidence suggests that gut microbiome dysbiosis, extracellular vesicle (EV) signaling, mitochondrial dysfunction, and epigenetic alterations contribute significantly to PMOS pathogenesis.
The objective is to investigate the integrated Gut microbiome–Extracellular Vesicle–Mitochondrial–Epigenetic (GEME) network underlying PMOS and identify clinically translatable, minimally invasive biomarkers for early diagnosis, risk stratification, and precision intervention.
The study is expected to identify novel biomarker signatures, elucidate PMOS mechanisms, construct an integrated GEME framework, and develop predictive models for disease classification and prognosis. The findings may enable earlier diagnosis, improved risk prediction, personalized therapeutic strategies, and enhanced reproductive healthcare for Indian women.
2. A cross-sectional analytical study to link the association between high dietary salt intake, hypertension, metabolic disorders and pre-eclampsia among rural women of Bengal. Submitted to ANRF as PI for funding.
Hypertension and metabolic disorders are increasing rapidly in rural India due to changing dietary patterns, sedentary lifestyles, and increased consumption of processed and high-salt foods. Excess dietary sodium intake is a recognized risk factor for hypertension and cardiovascular diseases; however, evidence regarding its association with metabolic disorders and pregnancy-related complications such as preeclampsia in rural Indian populations remains limited. Existing Indian studies primarily focus on urban populations or hospital-based samples and rarely integrate sodium intake assessment with maternal health and metabolic disease outcomes. Furthermore, rural communities are undergoing nutritional transitions characterized by increased consumption of preserved foods, packaged snacks, and sodium-rich traditional diets, yet there is insufficient epidemiological data assessing the combined burden of hypertension, metabolic syndrome, and preeclampsia in these populations. The lack of comprehensive rural data limits the development of targeted public health interventions and nutrition policies aimed at reducing sodium-related disease burden among vulnerable populations, especially women of reproductive age. Therefore, this study seeks to examine the relationship between high salt intake, hypertension, metabolic disorders, and preeclampsia among rural Indian populations to address existing research and policy gaps.
We hypothesize that Socio-demographic factors significantly influence sodium consumption patterns in rural populations which induces metabolic disorders, and an increased serum sodium levels significantly increases the risk of preeclampsia among pregnant women, which is of great concern.
3. Epigenetic Reprogramming Potential of Resveratrol in Polycystic Ovarian Syndrome: An In-Vitro Mechanistic Study. Submitted to ANRF for NPDF position. Where I am the host.
Polycystic Ovarian Syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder affecting women of reproductive age, characterized by hyperandrogenism, insulin resistance, chronic inflammation, and ovulatory dysfunction. Despite its high prevalence, existing therapeutic strategies remain largely symptomatic and fail to address the molecular mechanisms underlying disease persistence and intergenerational transmission. Emerging evidence highlights epigenetic dysregulation—including aberrant DNA methylation, altered histone modifications, and disrupted activity of epigenetic regulators—as a central driver of PCOS pathophysiology. Resveratrol, a naturally occurring polyphenolic stilbene, has gained considerable attention due to its potent antioxidant, anti-inflammatory, insulin-sensitizing, and epigenetic regulatory properties. Notably, resveratrol is a well-established activator of SIRT1, a key NAD?-dependent deacetylase implicated in steroidogenesis, mitochondrial function, oxidative stress regulation, and metabolic homeostasis in ovarian granulosa cells. Increasing experimental evidence suggests that resveratrol can modulate DNA methylation, histone acetylation, and microRNA expression, thereby influencing both reproductive and metabolic pathways relevant to PCOS. However, comprehensive mechanistic studies dissecting resveratrol-mediated epigenetic reprogramming in ovarian cells remain limited. The present proposal aims to investigate the epigenetic and functional effects of resveratrol in an in-vitro PCOS model using human and murine granulosa cells exposed to hyperandrogenic and hyperinsulinemic conditions. The study will evaluate resveratrol-induced changes in DNA methylation patterns, histone modifications, expression of epigenetic regulators—particularly SIRT1—and associated functional outcomes such as steroid hormone synthesis, insulin signaling efficiency, oxidative stress response, and inflammatory cytokine production. By employing cost-effective, high-throughput molecular and epigenetic approaches, this work seeks to generate robust mechanistic insights into resveratrol-based epigenetic intervention for PCOS and establish a strong preclinical foundation for future translational studies
I love teachingeverytopic of Human physiology emphasizing more on Reproductive Physiology, Endocrinology and Developmental Physiology specifically early embryonic development.. At the same time I take interest in teaching instrumentation to both UG and PG students.
Currently I have 4 PhD students, Two of them are about to submit their thesis, One of them will submit her 5000 soon. Currently I have 4 PhD positions availablable in my lab.
My lab scholars are
Dr. Chitrita Chatterjee (currently a faculty in Howrah College)
Mr. Chiranjit Nath (left midway to join as a faculty in Ranchi)
Ms. Namita Naskar will submit her 5000 soon
Piyali Majumdar is ready to submit her thesis.
Dr. Ishita Saha (MBBS, MD physiolgy) is ready to submit her thesis.
Life member of Indian Society for Studies in Reproduction and Fertility (ISSRF)
Life Member of Indian Association for biomedical Scientists (IABMS)
Life Member of Physiological Society of India (PSI)
Full Length Papers in peer reviewed journals:
Full Length Papers in peer reviewed journals:
1. S. Biswas, S. N. Kabir and Alok. K. Pal "The role of Nitric Oxide in the process of implantation in rats" Journal of reproduction and fertility.114; 157-161,1998.
2. Alok. K. Pal, Shampa Biswas, S.K. Goswami and Syed. N. Kabir " Effect of
Pelvic Endometrial implants on overall reproductive functions of female rats" Biology of Reproduction.60;954-958,1999.
3. M. Mukherjee, M. Dutta, S. Biswas, Alok. K. Pal, Dipankar Malakar, A.K. Bhattacharya, S. Bhattacharya and H. Kobayashi “Immotilin – A novel Sperm immobilizing protein” Fertility Sterility. Volume 79, supplement 3, June 2003.
4. Srabonti Kumar, Shampa Biswas, Debayan Mandal, Smritinath Chakraborty, Syed N. Kabir, Sukdeb Banerjee, Nirup Bikash Mandal Chenopodium album seed extract: A potent sperm immobilizing agent in vitro and in-vivo. Contraception, Volume 75, Issue 1, January 2007, Pages 71-78.
5. Srabonti Kumar, Shampa Biswas, Sukdeb Banerjee, Nirup Bikash Mandal. Evaluation of safety margins of Chenopodium album seed decoction: 14 day subacute toxicity and microbicidal activity. Reproductive Biology and endocrinology, volume 9:102; 2011.
6. “Pentamidine isethionate loaded mannosylated poly-lactide-co-glycolide
nanoparticles for effective management of visceral leishmaniasis.” Arindam Maity Shampa Biswas, Smritinath Chakraborty. Nirup B. Mondal, Sanchaita Lala Conference paper, OMICS 2011, Hyderabad 2011
7. Construction and application of mannose-grafted poly-DL-lactide-co-glycolide nanoparticles for active targeting of macrophages. ArindamMaity • Shampa Biswas, Smritinath Chakraborty, Nirup B. Mondal, Sanchaita Lala Conference paper, Mar 2011, IIT Guwahati 2011
8. Characterize heavy metal tolerant rhizospheric sewage bacteria isolated from Tolly nullah (with special emphasis on strain Microbacterium radiodurans K12016) Chitrita Chatterjee, Rabindranath Bhattacharyya, Shampa Sarkar (Biswas) International Journal of Engineering, Science and Mathematics Vol. 7 Special Issue 4(1), April 2018, ISSN: 2320-0294
9. Chatterjee chitrita, Upadhyay Sayantani, Bhattacharyya Rabindranath, Sarkar (Biswas) Shampa. Screening Heavy metal resistance and PGPR like traits of soil bacteria, isolated from Tolly Nullah, Kolkata, India. Journal of basic Microbiology.
10. Dalal S, Adhikary J, Roy A, Biswas SS, Mukhopadhyay PK, Acharya S, Ghosh
A. Impact of hyperglycemia on the expression of GLUT1 during oral carcinogenesis in rats. Mol Biol Rep. 2022;49(9):8369-8380. https://doi.org/10.1007/s11033-022-07653-1
11. Madhuchhanda Adhikari, Chayan Biswas, Piyali Mazumdar, Shampa Sarkar (B iswas), Kousik Pramanick. Evaluating the potential of daily intake of polystyrene microplastics via drinking water in inducing PCOS and its ovarian fibrosis progression using female zebrafish. Nanoimpact April 2024;34 10.1016/j.impact.2024.100507
12. Piyali Mazumdar, Shampa Sarkar Biswas. Melatonin: Adjunct therapeutics in ovarian endometrioma. IJPAS 2023; volume 3
13. Ishita Saha, Oly Banerjee, Shampa Sarkar (Biswas), Sandip Mukherjee, COVID-19 beyond the lungs: unraveling its vascular impact and cardiovascular complications – mechanisms and therapeutic implications Science Progress2025 Vol 108(1) 1-17 DOI 10.1177/00368504251322069 Journal Science Progress
14. Piyali Mazumdar, Shampa Sarkar Biswas. Ramipril ameliorates endometriosis by inducing oxidative stress mediated apoptosis in the wistar rat, Journal of Molecular Histology, March 2025. (2025) 56:117 https://doi.org/10.1007/s10735-025-10397-4.
15. Piyali Mazumdar, Shampa Sarkar Biswas. "Repurposing Ramipril to mitigate EMT like transition in endometriosis by PI3K/AKT/S6K1 signalling pathway: A study in endometriosis induced rats" January 2026 Naunyn-Schmiedeberg's Archives of Pharmacology DOI: 10.1007/s00210-026-05030-4
16. Ishita Saha , Rabindra Nath Dasb , Oly Banerjeec , Shampa Sarkar (Biswas) , Sandip Mukherjee. Joint generalized linear model analysis of hepatopancreatic markers: determinants of coronavirus disease 2019 severity and strategies for postrecovery care. Alexandria Journal of Medicine 2026, 61:1–9 DOI: 10.4103/AJOM.AJOM_76_25
17. Ishita Saha , Anirban Sinha , Anup Kumar Sadhu, Rabindra Nath Das , Satadru Ghosh , Priyajit Banerjee , Oly Banerjee , Shampa Sarkar Biswas , Sandip Mukherje8 and Palash Kumar Pal. Renal function dynamics in COVID-19: exploring biomarker interactions with D-dimer and C-reactive proteins. Bioscience Reports (2026) 46 BSR20254002 https://doi.org/10.1042/BSR20254002
18. Namita Naskar, Shampa Sarkar Biswas. “Nitric Oxide: an important regulator of extra cellular matrix modulation in ovarian follicle development” Accepted in Indian Journal of Physiology and Allied Sciences(IJPAS), June2026
International Patents:
An international patent has been filed on “A protein from the coelomic fluid of an Indian earth worm that causes immotility of Sperm”. Patent no. 241/NF/2001 dated 30.03.2001.
Presidency University Students Corner